{"id":34407,"date":"2024-10-23T09:30:55","date_gmt":"2024-10-23T01:30:55","guid":{"rendered":"https:\/\/jotbody.com\/nanobodies-pioneering-precision-in-opioid-receptor-targeting\/"},"modified":"2024-10-23T11:04:41","modified_gmt":"2024-10-23T03:04:41","slug":"nanobodies-pioneering-precision-in-opioid-receptor-targeting","status":"publish","type":"post","link":"https:\/\/jotbody.com\/cn\/nanobodies-pioneering-precision-in-opioid-receptor-targeting\/","title":{"rendered":"\u7eb3\u7c73\u6297\u4f53\uff1a\u5f00\u62d3\u5728\u963f\u7247\u53d7\u4f53\u9776\u5411\u4e0a\u7684\u7cbe\u51c6\u6027"},"content":{"rendered":"<p style=\"text-align: justify;\">\u5728\u5e7f\u9614\u7684\u836f\u7269\u53d1\u73b0\u9886\u57df\u4e2d\uff0c\u4e00\u9879\u6700\u8fd1\u5728\u300aNature Communications\u300b\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u63ed\u793a\u4e86\u4e00\u4e2a\u5728G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCRs\uff09\u9886\u57df\u7684\u663e\u8457\u7a81\u7834\uff0c\u91cd\u70b9\u5173\u6ce8\u03bc-\u963f\u7247\u53d7\u4f53\uff08\u03bcOR\uff09\u53ca\u5176\u4f7f\u7528\u7eb3\u7c73\u6297\u4f53\u8fdb\u884c\u9776\u5411\u8c03\u8282\u3002\u8fd9\u9879\u540d\u4e3a\u201c<a href=\"https:\/\/doi.org\/10.1038\/s41467-024-52947-6\" target=\"_blank\" rel=\"noopener\">Structural basis of \u03bc-opioid receptor targeting by a nanobody antagonist<\/a>\u201d\u7684\u7814\u7a76\u4ecb\u7ecd\u4e86\u4e00\u79cd\u5f15\u4eba\u5165\u80dc\u7684\u65b9\u6cd5\uff0c\u6709\u671b\u6539\u53d8\u963f\u7247\u7c7b\u9547\u75db\u836f\u9886\u57df\u3002<\/p>\n<p style=\"text-align: justify;\">\u03bc-\u963f\u7247\u53d7\u4f53\u662f\u836f\u7269\u9886\u57df\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u89d2\u8272\uff0c\u5728\u963f\u7247\u7c7b\u836f\u7269\u7684\u836f\u7406\u5b66\u9886\u57df\u4ee5\u5176\u76f8\u5173\u526f\u4f5c\u7528\u6240\u5e26\u6765\u7684\u6311\u6218\u800c\u95fb\u540d\u3002\u9488\u5bf9\u8fd9\u4e00\u96be\u9898\uff0c\u8be5\u7814\u7a76\u5f15\u5165\u4e86NbE\uff0c\u4e00\u79cd\u9009\u62e9\u6027\u7ed3\u5408\u03bcOR\u7ec6\u80de\u5916\u7ed3\u6784\u57df\u7684\u7eb3\u7c73\u6297\u4f53\uff0c\u6709\u6548\u5730\u4f5c\u4e3a\u62ee\u6297\u5242\u3002\u8fd9\u79cd\u65b0\u578b\u7eb3\u7c73\u6297\u4f53\u8868\u73b0\u51fa\u5bf9\u03bcOR\u7684\u9ad8\u4eb2\u548c\u529b\uff0c\u4e3a\u5f00\u53d1\u5177\u6709\u589e\u5f3a\u7597\u6548\u548c\u9009\u62e9\u6027\u7684\u9776\u5411\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6709\u5e0c\u671b\u7684\u9014\u5f84\u3002<\/p>\n<p style=\"text-align: justify;\">\u8fd9\u9879\u7814\u7a76\u7684\u4e00\u4e2a\u5173\u952e\u4eae\u70b9\u5728\u4e8e\u901a\u8fc7\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-EM\uff09\u5206\u6790NbE-\u03bcOR\u590d\u5408\u7269\u6240\u5b9e\u73b0\u7684\u7ed3\u6784\u63ed\u793a\u3002\u901a\u8fc7\u8fd9\u9879\u5206\u6790\uff0c\u7814\u7a76\u63ed\u793a\u4e86NbE\u5982\u4f55\u901a\u8fc7\u4e0e\u6b63\u4ea4\u4f4d\u888b\u548c\u7ec6\u80de\u5916\u53d7\u4f53\u73af\u76f8\u4e92\u4f5c\u7528\uff0c\u5c06\u03bcOR\u7a33\u5b9a\u5728\u4e00\u79cd\u975e\u6d3b\u6027\u6784\u8c61\u4e2d\uff0c\u8fd9\u4e0e\u4f20\u7edf\u7684\u5c0f\u5206\u5b50\u62ee\u6297\u5242\u6709\u6240\u4e0d\u540c\u3002\u8fd9\u4e9b\u5206\u5b50\u6d1e\u5bdf\u529b\u4e3a\u8bbe\u8ba1\u5206\u5b50\u91cf\u8f83\u5c0f\u7684\u914d\u4f53\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u4e3a\u672a\u6765\u7684\u6cbb\u7597\u521b\u65b0\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n<figure id=\"attachment_34399\" aria-describedby=\"caption-attachment-34399\" style=\"width: 685px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-34399 size-full\" src=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-1.webp?resize=640%2C232&#038;ssl=1\" alt=\"\" width=\"640\" height=\"232\" srcset=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-1.webp?w=685&amp;ssl=1 685w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-1.webp?resize=300%2C109&amp;ssl=1 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption id=\"caption-attachment-34399\" class=\"wp-caption-text\">Architecture of the NbE-\u00b5OR complex.<\/figcaption><\/figure>\n<p style=\"text-align: justify;\">\u8be5\u7814\u7a76\u8fd8\u5f3a\u8c03\u4e86NbE\u6240\u5c55\u793a\u7684\u72ec\u7279\u751f\u7269\u5206\u5b50\u8bc6\u522b\u7279\u5f81\uff0c\u5176\u7279\u70b9\u662f\u7f13\u6162\u7684\u8fdb\u5165\u901f\u7387\u548c\u51e0\u4e4e\u4e0d\u53ef\u9006\u7684\u7ed3\u5408\u3002\u8fd9\u4e00\u72ec\u7279\u7279\u5f81\u8868\u660eNbE\u5bf9\u03bcOR\u6d3b\u6027\u5177\u6709\u957f\u65f6\u95f4\u548c\u7279\u5f02\u6027\u7684\u62ee\u6297\u6548\u5e94\uff0c\u4f7f\u5176\u6210\u4e3a\u7ba1\u7406\u963f\u7247\u7c7b\u836f\u7269\u4f7f\u7528\u969c\u788d\u7684\u957f\u671f\u6cbb\u7597\u7b56\u7565\u7684\u6f5c\u5728\u5019\u9009\u8005\u3002NbE\u6a21\u62df\u4f2a\u4e0d\u53ef\u9006\u914d\u4f53\u7684\u6548\u679c\u7684\u6f5c\u529b\u4e3a\u51cf\u8f7b\u957f\u65f6\u95f4\u4f7f\u7528\u963f\u7247\u7c7b\u836f\u7269\u7684\u5f71\u54cd\u6253\u5f00\u4e86\u9014\u5f84\u3002<\/p>\n<p style=\"text-align: justify;\">\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u6982\u8ff0\u4e86\u4e00\u79cd\u5229\u7528NbE\u8c03\u8282\u7ec6\u80de\u5916\u8868\u8fbe\u65f6\u03bcOR\u6d3b\u6027\u7684\u7b56\u7565\uff0c\u63d0\u4f9b\u4e86\u4e00\u79cd\u591a\u529f\u80fd\u65b9\u6cd5\u6765\u6291\u5236\u795e\u7ecf\u5143\u6c34\u5e73\u4e0a\u7684\u03bcOR\u529f\u80fd\u3002\u901a\u8fc7\u5c06NbE\u4e0e\u4e9a\u7ec6\u80de\u5b9a\u4f4d\u57fa\u5e8f\u7ed3\u5408\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u60f3\u4e86\u4e00\u79cd\u7cbe\u786e\u5de5\u5177\uff0c\u53ef\u4ee5\u6df1\u5165\u7814\u7a76\u03bcOR\u4fe1\u53f7\u4f20\u5bfc\u7684\u590d\u6742\u6027\uff0c\u5b9e\u73b0\u5728\u53d7\u63a7\u5b9e\u9a8c\u5ba4\u73af\u5883\u548c\u4f53\u5185\u5b9e\u9a8c\u4e2d\u7684\u8be6\u7ec6\u529f\u80fd\u7814\u7a76\u3002<\/p>\n<figure id=\"attachment_34402\" aria-describedby=\"caption-attachment-34402\" style=\"width: 685px\" class=\"wp-caption aligncenter\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"wp-image-34402 size-full\" src=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2.webp?resize=640%2C604&#038;ssl=1\" alt=\"\" width=\"640\" height=\"604\" srcset=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2.webp?w=685&amp;ssl=1 685w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2.webp?resize=300%2C283&amp;ssl=1 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption id=\"caption-attachment-34402\" class=\"wp-caption-text\">CDR3-based peptide-mimetics exhibit \u00b5OR binding and antagonism.<\/figcaption><\/figure>\n<p style=\"text-align: justify;\">\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u7814\u7a76\u6240\u5448\u73b0\u7684\u53d1\u73b0\u7a81\u663e\u4e86\u7eb3\u7c73\u6297\u4f53\u5728GPCR\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u53d8\u9769\u529b\u91cf\uff0c\u7279\u522b\u662f\u5728\u9488\u5bf9\u03bc-\u963f\u7247\u53d7\u4f53\u65b9\u9762\u3002\u5bf9\u672a\u6765\u836f\u7269\u5f00\u53d1\u548c\u65b0\u9896\u9776\u5411\u7b56\u7565\u7684\u5f71\u54cd\uff0c\u8fd9\u9879\u7814\u7a76\u9884\u793a\u7740\u5728\u8ffd\u6c42\u6709\u6548\u548c\u9009\u62e9\u6027\u6cbb\u7597\u65b9\u9762\u5f00\u542f\u4e86\u4e00\u4e2a\u65b0\u65f6\u4ee3\u3002\u5b83\u4e3a\u5f00\u53d1\u66f4\u5b89\u5168\u3001\u66f4\u4e2a\u6027\u5316\u7684\u75bc\u75db\u7ba1\u7406\u548c\u4e0e\u963f\u7247\u76f8\u5173\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u7ebf\u5e0c\u671b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u5e7f\u9614\u7684\u836f\u7269\u53d1\u73b0\u9886\u57df\u4e2d\uff0c\u4e00\u9879\u6700\u8fd1\u5728\u300aNature Communications\u300b\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u63ed\u793a\u4e86\u4e00\u4e2a\u5728G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCRs\uff09\u9886\u57df\u7684\u663e\u8457\u7a81\u7834\uff0c\u91cd\u70b9\u5173\u6ce8\u03bc-\u963f\u7247\u53d7\u4f53\uff08\u03bcOR\uff09\u53ca\u5176\u4f7f\u7528\u7eb3\u7c73\u6297\u4f53\u8fdb\u884c\u9776\u5411\u8c03\u8282\u3002\u8fd9\u9879\u540d\u4e3a\u201cStructural basis of \u03bc-opioid receptor targeting by a nanobody antagonist\u201d\u7684\u7814\u7a76\u4ecb\u7ecd\u4e86\u4e00\u79cd\u5f15\u4eba\u5165\u80dc\u7684\u65b9\u6cd5\uff0c\u6709\u671b\u6539\u53d8\u963f\u7247\u7c7b\u9547\u75db\u836f\u9886\u57df\u3002<\/p>\n","protected":false},"author":4,"featured_media":34396,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"iawp_total_views":8,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[41],"tags":[],"event_categories":[104],"class_list":["post-34407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-cn","event_categories-latest-research-cn"],"acf":[],"yoast_head":"<!-- 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