{"id":34456,"date":"2024-10-28T10:06:33","date_gmt":"2024-10-28T02:06:33","guid":{"rendered":"https:\/\/jotbody.com\/small-extracellular-vesicles-metal-carriers-and-cell-messengers\/"},"modified":"2024-10-28T10:25:52","modified_gmt":"2024-10-28T02:25:52","slug":"small-extracellular-vesicles-metal-carriers-and-cell-messengers","status":"publish","type":"post","link":"https:\/\/jotbody.com\/cn\/small-extracellular-vesicles-metal-carriers-and-cell-messengers\/","title":{"rendered":"\u5c0f\u7ec6\u80de\u5916\u56ca\u6ce1\uff1a\u91d1\u5c5e\u8f7d\u4f53\u548c\u7ec6\u80de\u4fe1\u4f7f"},"content":{"rendered":"

\u6211\u4eec\u7ec6\u80de\u5185\u91d1\u5c5e\u7684\u590d\u6742\u821e\u8e48\u2014\u2014\u5bf9\u751f\u547d\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u8fc7\u91cf\u53ef\u80fd\u6709\u6bd2\u2014\u2014\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u5f15\u8d77\u79d1\u5b66\u5bb6\u7684\u6781\u5927\u5174\u8da3\u3002\u6700\u8fd1\u5728\u300aJournal of Extracellular Biology\u300b\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\uff0c\u9898\u4e3a\u201cSmall Extracellular Vesicles Contain Metals and Transfer Metal Intercellularly<\/a>\u201d\uff0c\u7531\u58a8\u5c14\u672c\u5927\u5b66\u7684Laura J. Vella\u56e2\u961f\u8fdb\u884c\uff0c\u63ed\u793a\u4e86\u8fd9\u573a\u91d1\u5c5e\u4ea4\u54cd\u4e50\u4e2d\u7684\u65b0\u89d2\u8272\uff1a\u5c0f\u7ec6\u80de\u5916\u56ca\u6ce1\uff08sEVs\uff09\u3002<\/p>\n

sEVs\u662f\u7ec6\u80de\u91ca\u653e\u7684\u5fae\u5c0f\u6c14\u6ce1\u72b6\u7ed3\u6784\uff0c\u4ee5\u5728\u7ec6\u80de\u4e4b\u95f4\u7a7f\u68ad\u5404\u79cd\u5206\u5b50\u800c\u95fb\u540d\u3002\u7136\u800c\uff0c\u5b83\u4eec\u7684\u91d1\u5c5e\u542b\u91cf\u76f4\u5230\u73b0\u5728\u4ecd\u7136\u662f\u4e2a\u8c1c\u3002Vella\u7684\u56e2\u961f\u6df1\u5165\u63a2\u8ba8\u4e86\u8fd9\u7247\u672a\u77e5\u9886\u57df\uff0c\u63ed\u793a\u4e86sEVs\u5185\u90e8\u7684\u91d1\u5c5e\u5b9d\u85cf\u2014\u2014\u50cf\u94dc\u3001\u94c1\u3001\u950c\u548c\u9530\u8fd9\u6837\u7684\u5fc5\u9700\u91d1\u5c5e\uff0c\u4ee5\u53ca\u975e\u5fc5\u9700\u548c\u6f5c\u5728\u6709\u6bd2\u7684\u91d1\u5c5e\uff0c\u6bd4\u5982\u954d\u3001\u949b\u548c\u94c5\u3002<\/p>\n

\u8be5\u7814\u7a76\u63ed\u793a\u4e86sEVs\u4e0d\u4ec5\u643a\u5e26\u5bf9\u7ec6\u80de\u529f\u80fd\u81f3\u5173\u91cd\u8981\u7684\u6c27\u5316\u8fd8\u539f\u6d3b\u6027\u91d1\u5c5e\uff0c\u800c\u4e14\u5177\u6709\u5c06\u8fd9\u4e9b\u91d1\u5c5e\u4ece\u7ec6\u80de\u4e4b\u95f4\u8f93\u51fa\u548c\u8f6c\u79fb\u7684\u80fd\u529b\u3002\u8fd9\u79cd\u7ec6\u80de\u95f4\u91d1\u5c5e\u4ea4\u6362\u53ef\u80fd\u5bf9\u6b63\u5e38\u751f\u7406\u8fc7\u7a0b\u548c\u75be\u75c5\u72b6\u6001\u90fd\u5177\u6709\u91cd\u8981\u5f71\u54cd\uff0c\u6f5c\u5728\u5730\u5f71\u54cd\u91d1\u5c5e\u7a33\u6001\u548c\u6c27\u5316\u5e94\u6fc0\u6c34\u5e73\u3002<\/p>\n

\u4e00\u4e2a\u4ee4\u4eba\u7740\u8ff7\u7684\u53d1\u73b0\u662f\u5728\u4ece\u4eba\u7c7b\u8840\u6d46\u548c\u725b\u5976\u4e2d\u5206\u79bb\u5f97\u5230\u7684sEVs\u4e2d\u5b58\u5728\u94c1\uff0c\u8fd9\u8868\u660e\u5176\u5728\u94c1\u7684\u8fd0\u8f93\u548c\u50a8\u5b58\u4e2d\u53d1\u6325\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u7a33\u5b9a\u540c\u4f4d\u7d20\u94c1\u7684\u7ed3\u5408\u8fdb\u5165sEVs\u7a81\u663e\u4e86\u5728sEV\u5f62\u6210\u8fc7\u7a0b\u4e2d\u91d1\u5c5e\u5305\u542b\u7684\u673a\u5236\u3002<\/p>\n

\"\"
Cells preloaded with 57Fe release sEVs enriched in 57Fe.<\/figcaption><\/figure>\n

\u94dc\uff0c\u53e6\u4e00\u4e2a\u5728\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u4e2d\u8d77\u5173\u952e\u4f5c\u7528\u7684\u91d1\u5c5e\uff0c\u4e5f\u88ab\u68c0\u6d4b\u5230\u5b58\u5728\u4e8esEVs\u4e2d\uff0c\u8fd8\u6709\u950c\u3001\u9530\u548c\u9541\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u50cf\u954d\u548c\u949b\u8fd9\u6837\u7684\u975e\u751f\u7406\u91d1\u5c5e\u4e5f\u88ab\u53d1\u73b0\uff0c\u6697\u793asEVs\u5728\u89e3\u6bd2\u7ec6\u80de\u514d\u53d7\u6709\u5bb3\u91d1\u5c5e\u6216\u5e2e\u52a9\u62b5\u6297\u673a\u5236\u65b9\u9762\u53ef\u80fd\u53d1\u6325\u4f5c\u7528\u3002<\/p>\n\n\n\n\n
\"\"<\/td>\n\"\"<\/td>\n<\/tr>\n
\n

Small EVs contain many essential metals<\/em><\/span><\/p>\n<\/td>\n

\n

Small EVs contain non-physiological and toxic metals<\/span><\/em><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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