{"id":34189,"date":"2024-10-16T10:55:47","date_gmt":"2024-10-16T02:55:47","guid":{"rendered":"https:\/\/jotbody.com\/nanobody-magnetogenetics-brain-circuit-precision\/"},"modified":"2024-10-16T12:22:41","modified_gmt":"2024-10-16T04:22:41","slug":"nanobody-magnetogenetics-brain-circuit-precision","status":"publish","type":"post","link":"https:\/\/jotbody.com\/es\/nanobody-magnetogenetics-brain-circuit-precision\/","title":{"rendered":"Nanocuerpo Magnetogen\u00e9tica: Precisi\u00f3n del circuito cerebral"},"content":{"rendered":"

En un estudio innovador publicado en Science Advances titulado “Bidirectional regulation of motor circuits using magnetogenetic gene therapy<\/a>“, cient\u00edficos han desarrollado un sistema avanzado que utiliza prote\u00ednas diminutas llamadas nanocuerpos para controlar la actividad cerebral en ambas direcciones. Este sistema combina un nanocuerpo especial que apunta a una prote\u00edna llamada ferritina con otra prote\u00edna llamada TRPV1, lo que permite a los investigadores ajustar finamente los circuitos cerebrales utilizando campos magn\u00e9ticos. El equipo de investigaci\u00f3n, liderado por Unda y sus colegas, logr\u00f3 una precisi\u00f3n incre\u00edble en la alteraci\u00f3n de las estructuras cerebrales profundas en ratones despiertos y en movimiento libre. Esto se logr\u00f3 mediante la entrega de un nanocuerpo \u00fanico (Nb) dise\u00f1ado para interactuar con la ferritina natural (Ft) vinculada al canal TRPV1 (Nb-Ft-TRPV1) a trav\u00e9s de un solo vector AAV.<\/p>\n

Su estudio revel\u00f3 que activar c\u00e9lulas cerebrales espec\u00edficas llamadas neuronas estriatop\u00e1lidas utilizando un m\u00e9todo magn\u00e9tico desencaden\u00f3 respuestas significativas de congelamiento en ratones, similares a otras t\u00e9cnicas establecidas como el uso de luz o productos qu\u00edmicos para controlar la actividad cerebral. Al aplicar campos magn\u00e9ticos con una intensidad de 180 militeslas (mT) generados por m\u00e1quinas de resonancia magn\u00e9tica (MRI) o un dispositivo de estimulaci\u00f3n magn\u00e9tica transcraneal (TMS) com\u00fanmente utilizado en terapia humana, los investigadores pudieron modificar el comportamiento de los ratones. Verificaron los cambios en la actividad cerebral mediante diversos medios como observaci\u00f3n de expresiones g\u00e9nicas espec\u00edficas, t\u00e9cnicas de imagen cerebral y monitoreo en tiempo real de la actividad neuronal.<\/p>\n

\"\"
Selective viral-mediated expression of Nb-Ft-TRVP1Ca2+<\/sup> in striatal iSPNs elicits parkinsonian motor behavior.<\/figcaption><\/figure>\n

Adem\u00e1s, los investigadores lograron activar de manera altamente espec\u00edfica las neuronas estriatop\u00e1lidas en ratones de tipo salvaje combinando un AAV retr\u00f3grado que codifica la recombinasa Cre con el constructo magnetogen\u00e9tico condicional a Cre. De manera notable, mejoraron exitosamente las funciones motoras en ratones con parkinsonismo al inhibir de forma no invasiva las neuronas del n\u00facleo subtal\u00e1mico (STN) utilizando un constructo modificado de nanocuerpo-TRPV1 que bloque\u00f3 la actividad neuronal.<\/p>\n

\"\"
Mutant Nb-Ft-TRPV1Cl\u2212<\/sup> inhibits neuronal activity of STN projection neurons and rescues motor impairment in parkinsonian mice.<\/figcaption><\/figure>\n

Este estudio introduce un m\u00e9todo emocionante para controlar con precisi\u00f3n los circuitos cerebrales en animales utilizando imanes, abriendo posibilidades para futuras aplicaciones terap\u00e9uticas en humanos. El trabajo de los investigadores destaca el potencial de los sistemas magn\u00e9ticos basados en nanocuerpos en la gesti\u00f3n de la actividad cerebral con una precisi\u00f3n notable, ofreciendo esperanza para tratamientos de vanguardia y avances en la investigaci\u00f3n y cuidado neurol\u00f3gico.<\/p>\n","protected":false},"excerpt":{"rendered":"

En un estudio innovador publicado en Science Advances titulado “Bidirectional regulation of motor circuits using magnetogenetic gene therapy”, cient\u00edficos han desarrollado un sistema avanzado que utiliza prote\u00ednas diminutas llamadas nanocuerpos para controlar la actividad cerebral en ambas direcciones.<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"iawp_total_views":10,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[106],"tags":[],"event_categories":[113],"class_list":["post-34189","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar","event_categories-latest-research-es"],"acf":[],"yoast_head":"\nNanocuerpo Magnetogen\u00e9tica: Precisi\u00f3n del circuito cerebral - 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