{"id":34386,"date":"2024-10-21T10:45:54","date_gmt":"2024-10-21T02:45:54","guid":{"rendered":"https:\/\/jotbody.com\/immunomodulatory-roles-of-platelet-derived-extracellular-vesicles\/"},"modified":"2024-10-21T11:36:23","modified_gmt":"2024-10-21T03:36:23","slug":"immunomodulatory-roles-of-platelet-derived-extracellular-vesicles","status":"publish","type":"post","link":"https:\/\/jotbody.com\/es\/immunomodulatory-roles-of-platelet-derived-extracellular-vesicles\/","title":{"rendered":"Roles Inmunomoduladores de las EVs Derivadas de Plaquetas"},"content":{"rendered":"<p style=\"text-align: justify;\">En el \u00e1mbito de la comunicaci\u00f3n celular, las ves\u00edculas extracelulares (EVs) han surgido como potentes mensajeros que transportan carga biol\u00f3gica entre c\u00e9lulas. Entre ellas, las ves\u00edculas extracelulares derivadas de plaquetas (PEVs) han estado tradicionalmente asociadas con la hemostasia y la trombosis. Sin embargo, un estudio reciente realizado por el equipo de Pia R.-M. Siljander de la Universidad de Helsinki ha profundizado en las funciones inmunomoduladoras de los PEVs, revelando una interacci\u00f3n compleja y matizada con el sistema inmunitario m\u00e1s all\u00e1 de sus roles convencionales.<\/p>\n<p style=\"text-align: justify;\">El estudio, titulado &#8220;<a href=\"https:\/\/doi.org\/10.1002\/jev2.12513\" target=\"_blank\" rel=\"noopener\">Beyond basic characterization and omics: Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing<\/a>&#8220;, arroja luz sobre c\u00f3mo la activaci\u00f3n de las plaquetas a trav\u00e9s de diferentes receptores conduce a la generaci\u00f3n de PEVs con perfiles inmunomoduladores distintos. Al emplear ensayos funcionales en embriones de pez cebra y macr\u00f3fagos humanos, los investigadores descubrieron variaciones significativas en las respuestas desencadenadas por los PEVs producidos a trav\u00e9s de diferentes v\u00edas de activaci\u00f3n.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-34376 size-full\" src=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-4.jpg?resize=640%2C957&#038;ssl=1\" alt=\"\" width=\"640\" height=\"957\" srcset=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-4.jpg?w=1000&amp;ssl=1 1000w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-4.jpg?resize=201%2C300&amp;ssl=1 201w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-4.jpg?resize=685%2C1024&amp;ssl=1 685w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/1-4.jpg?resize=768%2C1148&amp;ssl=1 768w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/td>\n<td style=\"width: 50%;\"><img data-recalc-dims=\"1\" decoding=\"async\" class=\"aligncenter wp-image-34380 size-full\" src=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?resize=640%2C765&#038;ssl=1\" alt=\"\" width=\"640\" height=\"765\" srcset=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?w=1300&amp;ssl=1 1300w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?resize=251%2C300&amp;ssl=1 251w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?resize=857%2C1024&amp;ssl=1 857w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?resize=768%2C918&amp;ssl=1 768w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/10\/2-3.jpg?resize=1285%2C1536&amp;ssl=1 1285w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 50%;\"><span style=\"font-size: 10pt;\"><em>Interaction of macrophages with PEVs in vivo.<\/em><\/span><\/td>\n<td style=\"width: 50%;\"><span style=\"font-size: 10pt;\"><em>Changes in the macrophage cytokine secretomes induced by the different PEV types.<\/em><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\">Una de las revelaciones clave del estudio fue el descubrimiento de un perfil inmunomodulador \u00fanico exhibido por los PEVs liberados constitutivamente, los cuales se forman sin activaci\u00f3n externa. Este hallazgo subraya la diversidad y plasticidad de los PEVs y enfatiza la necesidad de un enfoque multifac\u00e9tico que vaya m\u00e1s all\u00e1 de los an\u00e1lisis omics tradicionales y las caracterizaciones fisicoqu\u00edmicas.<\/p>\n<p style=\"text-align: justify;\">El estudio destaca la importancia de realizar ensayos funcionales sensibles para comprender completamente los roles inmunomoduladores de los PEVs, especialmente en casos donde existen diferencias moleculares sutiles entre los tipos de PEVs generados a partir de plaquetas activadas. Al demostrar la capacidad de ajuste de los PEVs a trav\u00e9s de la activaci\u00f3n mediada por receptores y los posibles efectos enmascaradores de activaciones secundarias o v\u00edas de se\u00f1alizaci\u00f3n, la investigaci\u00f3n subraya la naturaleza intrincada de estas diminutas ves\u00edculas en la modulaci\u00f3n de las respuestas inmunitarias.<\/p>\n<p style=\"text-align: justify;\">Adem\u00e1s, el estudio sugiere la presencia de aspectos inexplorados como el lipidoma, metaboloma y glicosignaturas de los PEVs, los cuales podr\u00edan contribuir a la variabilidad observada en sus funciones inmunomoduladoras. Los hallazgos sugieren que una comprensi\u00f3n hol\u00edstica del PEVoma en diferentes contextos fisiol\u00f3gicos es crucial para desentra\u00f1ar la compleja red de interacciones entre los PEVs y las c\u00e9lulas inmunitarias.<\/p>\n<p style=\"text-align: justify;\">En conclusi\u00f3n, este estudio no solo ampl\u00eda nuestra comprensi\u00f3n de los roles inmunomoduladores de los PEVs, sino que tambi\u00e9n subraya la importancia de integrar ensayos funcionales junto con an\u00e1lisis moleculares para obtener una visi\u00f3n integral de las funciones biol\u00f3gicas de estos fascinantes mensajeros extracelulares. A medida que continuamos desvelando los misterios de los EVs, especialmente de los PEVs, abrimos nuevas v\u00edas para explorar su potencial terap\u00e9utico y aprovechar sus capacidades regulatorias en la modulaci\u00f3n de las respuestas inmunitarias.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>En el \u00e1mbito de la comunicaci\u00f3n celular, las ves\u00edculas extracelulares (EVs) han surgido como potentes mensajeros que transportan carga biol\u00f3gica entre c\u00e9lulas. Entre ellas, las ves\u00edculas extracelulares derivadas de plaquetas (PEVs) han estado tradicionalmente asociadas con la hemostasia y la trombosis. Sin embargo, un estudio reciente realizado por el equipo de Pia R.-M. Siljander de la Universidad de Helsinki ha profundizado en las funciones inmunomoduladoras de los PEVs, revelando una interacci\u00f3n compleja y matizada con el sistema inmunitario m\u00e1s all\u00e1 de sus roles convencionales.<\/p>\n","protected":false},"author":4,"featured_media":34375,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"iawp_total_views":5,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[106],"tags":[],"event_categories":[113],"class_list":["post-34386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","event_categories-latest-research-es"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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