{"id":34529,"date":"2024-11-04T11:41:41","date_gmt":"2024-11-04T03:41:41","guid":{"rendered":"https:\/\/jotbody.com\/the-potential-of-bacterial-extracellular-vesicles-as-postbiotics\/"},"modified":"2024-11-04T12:09:36","modified_gmt":"2024-11-04T04:09:36","slug":"the-potential-of-bacterial-extracellular-vesicles-as-postbiotics","status":"publish","type":"post","link":"https:\/\/jotbody.com\/es\/the-potential-of-bacterial-extracellular-vesicles-as-postbiotics\/","title":{"rendered":"Potencial de las EV bacterianas como postbi\u00f3ticos"},"content":{"rendered":"<p>En un estudio reciente publicado en el <i>Journal of Extracellular Vesicles<\/i> titulado \u201c<a href=\"https:\/\/isevjournals.onlinelibrary.wiley.com\/doi\/10.1002\/jev2.70004\">Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells<\/a>\u201d, Irma Schabussova y su equipo de la Universidad de Viena exploran el \u00e1mbito de los probi\u00f3ticos y su potencial como terapias postbi\u00f3ticas. La investigaci\u00f3n se centra en <i>Escherichia coli<\/i> A0 34\/86 (EcO83), una cepa probi\u00f3tica conocida por su eficacia en la prevenci\u00f3n de infecciones y la reducci\u00f3n de la inflamaci\u00f3n al\u00e9rgica en las v\u00edas respiratorias, especialmente en reci\u00e9n nacidos.<\/p>\n<p>Los probi\u00f3ticos vivos han mostrado resultados prometedores en diversas aplicaciones, pero las preocupaciones sobre infecciones sist\u00e9micas y la transferencia de genes han llevado a los investigadores a explorar alternativas. Las ves\u00edculas extracelulares (EVs) derivadas de EcO83, denominadas EcO83-EVs, han surgido como una alternativa potencialmente m\u00e1s segura a las bacterias vivas. Estas EVs fueron aisladas, purificadas y caracterizadas siguiendo pautas estrictas, destacando su potencial como terapias postbi\u00f3ticas.<\/p>\n<p>A trav\u00e9s de una serie de experimentos, los investigadores demostraron que las EcO83-EVs interact\u00faan de manera efectiva con las c\u00e9lulas del hu\u00e9sped, mostrando un aumento en la expresi\u00f3n de prote\u00ednas asociadas con el estr\u00e9s oxidativo y la inflamaci\u00f3n. Los estudios in vivo en ratones revelaron que las EcO83-EVs interact\u00faan con el tejido linfoide asociado a la mucosa nasal, son internalizadas por los macr\u00f3fagos de las v\u00edas respiratorias y estimulan el reclutamiento de neutr\u00f3filos en el pulm\u00f3n. Mec\u00e1nicamente, las EcO83-EVs activan la v\u00eda de se\u00f1alizaci\u00f3n NF-\u03ba\u0392, lo que conduce a la producci\u00f3n de \u00f3xido n\u00edtrico.<\/p>\n<p><img data-recalc-dims=\"1\" fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-34517\" src=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?resize=375%2C584&#038;ssl=1\" alt=\"\" width=\"375\" height=\"584\" srcset=\"https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?w=1000&amp;ssl=1 1000w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?resize=193%2C300&amp;ssl=1 193w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?resize=659%2C1024&amp;ssl=1 659w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?resize=768%2C1194&amp;ssl=1 768w, https:\/\/i0.wp.com\/jotbody.com\/wp-content\/uploads\/2024\/11\/1.jpg?resize=988%2C1536&amp;ssl=1 988w\" sizes=\"(max-width: 375px) 100vw, 375px\" \/><\/p>\n<p>El estudio subraya el potencial significativo de las EcO83-EVs como una alternativa postbi\u00f3tica, ofreciendo una opci\u00f3n m\u00e1s segura para aplicaciones terap\u00e9uticas en comparaci\u00f3n con las bacterias vivas. Los hallazgos sugieren que estas EVs podr\u00edan tener aplicaciones en la vacunaci\u00f3n mucosal y en estrategias de inmunoterapia dirigida, abriendo nuevas v\u00edas para la investigaci\u00f3n y la exploraci\u00f3n cl\u00ednica.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>En un estudio reciente publicado en el Journal of Extracellular Vesicles titulado \u201cBacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells\u201d, Irma Schabussova y su equipo de la Universidad de Viena exploran el \u00e1mbito de los probi\u00f3ticos y su potencial como terapias postbi\u00f3ticas. La investigaci\u00f3n se centra en Escherichia coli A0 34\/86 (EcO83), una cepa probi\u00f3tica conocida por su eficacia en la prevenci\u00f3n de infecciones y la reducci\u00f3n de la inflamaci\u00f3n al\u00e9rgica en las v\u00edas respiratorias, especialmente en reci\u00e9n nacidos.<\/p>\n","protected":false},"author":4,"featured_media":34525,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"iawp_total_views":8,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false,"jetpack_post_was_ever_published":false},"categories":[106],"tags":[],"event_categories":[113],"class_list":["post-34529","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar","event_categories-latest-research-es"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - 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