Innovation
and
Technology
and
Technology
Patent
- High-affinity anti-EGFP and anti-SARS-CoV-2 vNAR single domain antibodies and use thereof. PCT/CN2021/128297
- Method of Producing Antibody Fragment. CN201811318557.4
- Specific primer pairs designed for single variable new antigen receptor domain derived from IgNAR of Chiloscyllium plagiosum. CN111197074A
- Method of Producing Antibody Fragment. US20190135904
Selected Publication
- Bamboo sharks for affordable single domain antibody production. Front. Bioeng. Biotechnol. 9:792111
- Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy. Theranostics. 2022 Apr 11;12(7):3288-3315. doi:10.7150/thno.68667. PMID: PMC9065173.
- Cas9-based local enrichment and genomics sequence revision of megabase-size shark immunoglobulin new antigen receptor loci. J Immunol. 2022 Jan 1;208(1):181-189
- Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery. J Extracell Vesicles. 2021;10:e12057
- The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish. iScience. 2020;23(11):101754
- The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats. Clin Trans Med. 2020;9:16