Latest Research

Extracellular vesicles (EVs) are pivotal in biomarker discovery, drug delivery, and regenerative medicine. However, maintaining their structural integrity and biological function remains a major challenge. A recent study published in Journal of Biological Engineering highlights the critical impact of storage conditions on EV bioavailability, shedding light on the risks of EV degradation and altered cargo profiles due to suboptimal preservation.

Introduction How can extracellular vesicles (EVs) be engineered for precise, targeted cancer therapy? Traditional drug delivery systems lack specificity, often leading to off-target effects and toxicity. A new study in Nature Biomedical Engineering introduces a novel approach—engineering EVs to display therapeutic antibodies, significantly enhancing targeted drug delivery and cellular uptake.

Introduction Gram-negative bacteria pose a significant global health threat due to their antibiotic resistance. One major factor is the New Delhi metallo-β-lactamase-1 (NDM-1) enzyme, which neutralizes carbapenem antibiotics, a last line of defence against bacterial infections. A recent study published in Molecules highlights nanobody-based inhibitors as a promising solution to target NDM-1 and restore antibiotic efficacy.